3. Particularly Hazardous Substances (PHS)

The Laboratory Standard states that: “The Chemical Hygiene Plan shall include... provisions for additional employee protection for work with hazardous substances, including “select carcinogens,” reproductive toxins and substances which have a high degree of acute toxicity

SELECT CARCINOGENS— Includes carcinogens as listed by the following organizations: OSHA; the National Toxicology Program; the International Agency for Research on Cancer. See also Sec. II.

REPRODUCTIVE TOXINS— A chemical which affects human reproductive capabilities, including chromosomal damage (mutations) and effects on fetuses (teratogenesis).

HIGH ACUTE TOXICITY SUBSTANCES— Substances such as hydrogen cyanide or hydrogen sulfide which may be fatal or cause damage to target organs as a result of a single exposure or exposures of short duration.

It is the responsibility of individual lab supervisors to institute SOPs for using a specific Particularly Hazardous Substance in their laboratories. See Section I for template forms and instructions.

The PHS section of the Lab Standard goes on to say: “ Specific consideration should be given to the following provisions which shall be incorporated where appropriate:

  1. “Establishment of a designated area”
  2. “Use of containment devices such as fume hoods or glove boxes”
  3. “Procedures for safe removal of contaminated waste”
  4. “Decontamination procedures”

Again, directions/prompts for addressing these issues is provided in the SOP development section (Sec. I).